Zebrafish has been a favored species in developmental biology and numerous genetic tools have been developed for this species over the past two decades. Zebrafish is small, easy to maintain, and prolific, attributes that make this species particularly amenable for high throughput screening. Indeed, numerous mutagenesis studies have been conducted in which mutation induced changes could be detected after the screening of thousands of fish. Most of these studies, however, focused on embryological questions. Given that zebrafish is a vertebrate organism with brain structure and function similar to other vertebrates, it should be an excellent study species for neuroscience and behavioral neuroscience too. However, the behavior of this species is rarely studied and behavioral test and quantification methods were previously unavailable. Behavioral tests that can tap into a diverse set of brain functions and the development of high throughput or automatable versions of such tests would be an important step. These tests would allow one to conduct large scale mutagenesis studies with a focus on brain function and would also allow one to test a large number of candidate compounds (small molecules) in pre-clinical drug screening studies. The symposium will bring together a number of experts in the rather small but rapidly developing zebra fish behavioral neuroscience field. These experts will present their latest behavioral test designs and discuss the technical aspects of how to make the tests high throughput. Furthermore, they will present their latest discoveries that could be made only with the use of the novel test paradigms.